diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 0e32438..cf4ec3f 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -20,7 +20,11 @@ jobs:
         options: --health-cmd=pg_isready --health-interval 10s --health-timeout 5s --health-retries 5
     strategy:
       matrix:
-        python-version: ["3.8", "3.9", "3.10", "3.11", "3.12"]
+        python-version: ["3.8", "3.9", "3.10", "3.11", "3.12", "3.13"]
+        tortoise-orm:
+          - tortoise021
+          - tortoise022
+          - tortoisedev
     steps:
       - name: Start MySQL
         run: sudo systemctl start mysql.service
@@ -38,6 +42,17 @@ jobs:
         run: |
           pip install -U pip poetry
           poetry config virtualenvs.create false
+      - name: Install dependencies and check style
+        run: make check
+      - name: Install TortoiseORM v0.21
+        if: matrix.tortoise-orm == 'tortoise021'
+        run: poetry run pip install --upgrade "tortoise-orm>=0.21,<0.22"
+      - name: Install TortoiseORM v0.22
+        if: matrix.tortoise-orm == 'tortoise022'
+        run: poetry run pip install --upgrade "tortoise-orm>=0.22,<0.23"
+      - name: Install TortoiseORM develop branch
+        if: matrix.tortoise-orm == 'tortoisedev'
+        run: poetry run pip install --upgrade "git+https://github.com/tortoise/tortoise-orm"
       - name: CI
         env:
           MYSQL_PASS: root
@@ -46,4 +61,4 @@ jobs:
           POSTGRES_PASS: 123456
           POSTGRES_HOST: 127.0.0.1
           POSTGRES_PORT: 5432
-        run: make ci
+        run: make _testall
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 5029231..2e985ce 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -19,6 +19,7 @@
 
 #### Changed
 - Allow run `aerich init-db` with empty migration directories instead of abort with warnings. (#286)
+- Add version constraint(>=0.21) for tortoise-orm. (#388)
 - Move `tomlkit` to optional and support `pip install aerich[toml]`. (#392)
 
 ### [0.8.0](../../releases/tag/v0.8.0) - 2024-12-04
diff --git a/conftest.py b/conftest.py
index 8518f79..f87aa26 100644
--- a/conftest.py
+++ b/conftest.py
@@ -8,6 +8,7 @@ from tortoise import Tortoise, expand_db_url, generate_schema_for_client
 from tortoise.backends.asyncpg.schema_generator import AsyncpgSchemaGenerator
 from tortoise.backends.mysql.schema_generator import MySQLSchemaGenerator
 from tortoise.backends.sqlite.schema_generator import SqliteSchemaGenerator
+from tortoise.contrib.test import MEMORY_SQLITE
 from tortoise.exceptions import DBConnectionError, OperationalError
 
 from aerich.ddl.mysql import MysqlDDL
@@ -15,7 +16,6 @@ from aerich.ddl.postgres import PostgresDDL
 from aerich.ddl.sqlite import SqliteDDL
 from aerich.migrate import Migrate
 
-MEMORY_SQLITE = "sqlite://:memory:"
 db_url = os.getenv("TEST_DB", MEMORY_SQLITE)
 db_url_second = os.getenv("TEST_DB_SECOND", MEMORY_SQLITE)
 tortoise_orm = {
diff --git a/poetry.lock b/poetry.lock
index cff25a0..8acfeef 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -1189,4 +1189,4 @@ toml = ["tomli-w", "tomlkit"]
 [metadata]
 lock-version = "2.0"
 python-versions = "^3.8"
-content-hash = "6debce184c7fb1fa5cfb79083a35bf2fe6b2f87dea29f3e8e8e23189bed744b5"
+content-hash = "5a17cf1dd79829b76fc2c71cbd83032d70ada4f129cf56973c417eac91a975f6"
diff --git a/pyproject.toml b/pyproject.toml
index 9c1d154..2185b48 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -16,7 +16,7 @@ include = ["CHANGELOG.md", "LICENSE", "README.md"]
 
 [tool.poetry.dependencies]
 python = "^3.8"
-tortoise-orm = "*"
+tortoise-orm = ">=0.21"
 asyncpg = { version = "*", optional = true }
 asyncmy = { version = "^0.2.9", optional = true, allow-prereleases = true }
 pydantic = "^2.0,!=2.7.0"