diff --git a/src/betterproto/grpc/grpclib_server.py b/src/betterproto/grpc/grpclib_server.py
new file mode 100644
index 0000000..59bc7d4
--- /dev/null
+++ b/src/betterproto/grpc/grpclib_server.py
@@ -0,0 +1,30 @@
+from abc import ABC
+from collections import AsyncIterable
+from typing import Callable, Any, Dict
+
+import grpclib
+import grpclib.server
+
+
+class ServiceBase(ABC):
+    """
+    Base class for async gRPC servers.
+    """
+
+    async def _call_rpc_handler_server_stream(
+        self,
+        handler: Callable,
+        stream: grpclib.server.Stream,
+        request_kwargs: Dict[str, Any],
+    ) -> None:
+
+        response_iter = handler(**request_kwargs)
+        # check if response is actually an AsyncIterator
+        # this might be false if the method just returns without
+        # yielding at least once
+        # in that case, we just interpret it as an empty iterator
+        if isinstance(response_iter, AsyncIterable):
+            async for response_message in response_iter:
+                await stream.send_message(response_message)
+        else:
+            response_iter.close()
diff --git a/src/betterproto/plugin/models.py b/src/betterproto/plugin/models.py
index 8d487a4..09217b9 100644
--- a/src/betterproto/plugin/models.py
+++ b/src/betterproto/plugin/models.py
@@ -553,6 +553,7 @@ class ServiceCompiler(ProtoContentBase):
     def __post_init__(self) -> None:
         # Add service to output file
         self.output_file.services.append(self)
+        self.output_file.typing_imports.add("Dict")
         super().__post_init__()  # check for unset fields
 
     @property
diff --git a/src/betterproto/templates/template.py.j2 b/src/betterproto/templates/template.py.j2
index 753d340..de53963 100644
--- a/src/betterproto/templates/template.py.j2
+++ b/src/betterproto/templates/template.py.j2
@@ -15,6 +15,7 @@ from typing import {% for i in output_file.typing_imports|sort %}{{ i }}{% if no
 {% endif %}
 
 import betterproto
+from betterproto.grpc.grpclib_server import ServiceBase
 {% if output_file.services %}
 import grpclib
 {% endif %}
@@ -82,7 +83,7 @@ class {{ service.py_name }}Stub(betterproto.ServiceStub):
                                             Optional[{{ field.annotation }}]
                                          {%- else -%}
                                             {{ field.annotation }}
-                                         {%- endif -%} = 
+                                         {%- endif -%} =
                                             {%- if field.py_name not in method.mutable_default_args -%}
                                                 {{ field.default_value_string }}
                                             {%- else -%}
@@ -154,6 +155,89 @@ class {{ service.py_name }}Stub(betterproto.ServiceStub):
     {% endfor %}
 {% endfor %}
 
+{% for service in output_file.services %}
+class {{ service.py_name }}Base(ServiceBase):
+    {% if service.comment %}
+{{ service.comment }}
+
+    {% endif %}
+
+    {% for method in service.methods %}
+    async def {{ method.py_name }}(self
+        {%- if not method.client_streaming -%}
+            {%- if method.py_input_message and method.py_input_message.fields -%},
+                {%- for field in method.py_input_message.fields -%}
+                    {{ field.py_name }}: {% if field.py_name in method.mutable_default_args and not field.annotation.startswith("Optional[") -%}
+                                            Optional[{{ field.annotation }}]
+                                         {%- else -%}
+                                            {{ field.annotation }}
+                                         {%- endif -%}
+                    {%- if not loop.last %}, {% endif -%}
+                {%- endfor -%}
+            {%- endif -%}
+        {%- else -%}
+            {# Client streaming: need a request iterator instead #}
+            , request_iterator: AsyncIterator["{{ method.py_input_message_type }}"]
+        {%- endif -%}
+            ) -> {% if method.server_streaming %}AsyncIterator["{{ method.py_output_message_type }}"]{% else %}"{{ method.py_output_message_type }}"{% endif %}:
+        {% if method.comment %}
+{{ method.comment }}
+
+        {% endif %}
+        raise grpclib.GRPCError(grpclib.const.Status.UNIMPLEMENTED)
+
+    {% endfor %}
+
+    {% for method in service.methods %}
+    async def __rpc_{{ method.py_name }}(self, stream: grpclib.server.Stream) -> None:
+        {% if not method.client_streaming %}
+        request = await stream.recv_message()
+
+        request_kwargs = {
+        {% for field in method.py_input_message.fields %}
+            "{{ field.py_name }}": request.{{ field.py_name }},
+        {% endfor %}
+        }
+
+        {% else %}
+        request_kwargs = {"request_iterator": stream.__aiter__()}
+        {% endif %}
+
+        {% if not method.server_streaming %}
+        response = await self.{{ method.py_name }}(**request_kwargs)
+        await stream.send_message(response)
+        {% else %}
+        await self._call_rpc_handler_server_stream(
+            self.{{ method.py_name }},
+            stream,
+            request_kwargs,
+        )
+        {% endif %}
+
+    {% endfor %}
+
+    def __mapping__(self) -> Dict[str, grpclib.const.Handler]:
+        return {
+        {% for method in service.methods %}
+        "{{ method.route }}": grpclib.const.Handler(
+            self.__rpc_{{ method.py_name }},
+            {% if not method.client_streaming and not method.server_streaming %}
+            grpclib.const.Cardinality.UNARY_UNARY,
+            {% elif not method.client_streaming and method.server_streaming %}
+            grpclib.const.Cardinality.UNARY_STREAM,
+            {% elif method.client_streaming and not method.server_streaming %}
+            grpclib.const.Cardinality.STREAM_UNARY,
+            {% else %}
+            grpclib.const.Cardinality.STREAM_STREAM,
+            {% endif %}
+            {{ method.py_input_message_type }},
+            {{ method.py_output_message_type }},
+        ),
+        {% endfor %}
+        }
+
+{% endfor %}
+
 {% for i in output_file.imports|sort %}
 {{ i }}
 {% endfor %}
diff --git a/tests/inputs/config.py b/tests/inputs/config.py
index 7d14667..9b7b288 100644
--- a/tests/inputs/config.py
+++ b/tests/inputs/config.py
@@ -17,4 +17,5 @@ services = {
     "import_service_input_message",
     "googletypes_service_returns_empty",
     "googletypes_service_returns_googletype",
+    "example_service",
 }
diff --git a/tests/inputs/example_service/example_service.proto b/tests/inputs/example_service/example_service.proto
new file mode 100644
index 0000000..96455cc
--- /dev/null
+++ b/tests/inputs/example_service/example_service.proto
@@ -0,0 +1,20 @@
+syntax = "proto3";
+
+package example_service;
+
+service Test {
+  rpc ExampleUnaryUnary(ExampleRequest) returns (ExampleResponse);
+  rpc ExampleUnaryStream(ExampleRequest) returns (stream ExampleResponse);
+  rpc ExampleStreamUnary(stream ExampleRequest) returns (ExampleResponse);
+  rpc ExampleStreamStream(stream ExampleRequest) returns (stream ExampleResponse);
+}
+
+message ExampleRequest {
+  string example_string = 1;
+  int64  example_integer = 2;
+}
+
+message ExampleResponse {
+  string example_string = 1;
+  int64  example_integer = 2;
+}
diff --git a/tests/inputs/example_service/test_example_service.py b/tests/inputs/example_service/test_example_service.py
new file mode 100644
index 0000000..12d646b
--- /dev/null
+++ b/tests/inputs/example_service/test_example_service.py
@@ -0,0 +1,95 @@
+from typing import AsyncIterator, AsyncIterable
+
+import pytest
+from grpclib.testing import ChannelFor
+
+from tests.output_betterproto.example_service.example_service import (
+    TestBase,
+    TestStub,
+    ExampleRequest,
+    ExampleResponse,
+)
+
+
+class ExampleService(TestBase):
+    async def example_unary_unary(
+        self, example_string: str, example_integer: int
+    ) -> "ExampleResponse":
+        return ExampleResponse(
+            example_string=example_string,
+            example_integer=example_integer,
+        )
+
+    async def example_unary_stream(
+        self, example_string: str, example_integer: int
+    ) -> AsyncIterator["ExampleResponse"]:
+        response = ExampleResponse(
+            example_string=example_string,
+            example_integer=example_integer,
+        )
+        yield response
+        yield response
+        yield response
+
+    async def example_stream_unary(
+        self, request_iterator: AsyncIterator["ExampleRequest"]
+    ) -> "ExampleResponse":
+        async for example_request in request_iterator:
+            return ExampleResponse(
+                example_string=example_request.example_string,
+                example_integer=example_request.example_integer,
+            )
+
+    async def example_stream_stream(
+        self, request_iterator: AsyncIterator["ExampleRequest"]
+    ) -> AsyncIterator["ExampleResponse"]:
+        async for example_request in request_iterator:
+            yield ExampleResponse(
+                example_string=example_request.example_string,
+                example_integer=example_request.example_integer,
+            )
+
+
+@pytest.mark.asyncio
+async def test_calls_with_different_cardinalities():
+    test_string = "test string"
+    test_int = 42
+
+    async with ChannelFor([ExampleService()]) as channel:
+        stub = TestStub(channel)
+
+        # unary unary
+        response = await stub.example_unary_unary(
+            example_string="test string",
+            example_integer=42,
+        )
+        assert response.example_string == test_string
+        assert response.example_integer == test_int
+
+        # unary stream
+        async for response in stub.example_unary_stream(
+            example_string="test string",
+            example_integer=42,
+        ):
+            assert response.example_string == test_string
+            assert response.example_integer == test_int
+
+        # stream unary
+        request = ExampleRequest(
+            example_string=test_string,
+            example_integer=42,
+        )
+
+        async def request_iterator():
+            yield request
+            yield request
+            yield request
+
+        response = await stub.example_stream_unary(request_iterator())
+        assert response.example_string == test_string
+        assert response.example_integer == test_int
+
+        # stream stream
+        async for response in stub.example_stream_stream(request_iterator()):
+            assert response.example_string == test_string
+            assert response.example_integer == test_int